Nitric Oxide

Nitric Oxide

How does Nitric Oxide contribute to heart health, and 5 Ways To Increase Nitric Oxide levels! 

Nitric oxide is  a major key to heart health.  It expands blood vessels, increases blood flow and keeps blood pressure normal. Nobel prizes have been awarded for its discovery and it has been designated as a “molecule of the year.” (1)  

A major pathway for its production uses L arginine and an enzyme called eNOS.  

To optimize this biochemical pathway, eight or so other “cofactors” are required.  So getting enough L arginine won’t help as much if the other ingredients of this recipe are deficient. 

These include folic acid and some others, all of which we can get from eating real whole foods. 

6 SIMPLE WAYS TO INCREASE NITRIC OXIDE:

  1. Eat beet root, arugula, spinach, radishes, carrots and greens.
  2. Eat dark chocolate.  Who said healthy foods aren’t the most enjoyable to eat??
  3. Maintain an optimal vitamin D3 level.  We feel taking supplemental vitamin D3 is safer than a lot of sun exposure because of the risk of skin cancer. 
  4. Drink pomegranate juice. We can reduce artery blockage to a degree with this. DRILL DOWN
  5. Take grape seed extract. This is concentrated enough to give a meaningful increase in nitric oxide. It also helps maintain the optimal testosterone levels needed by both men and women.  
  6. Eat omega 3’s. Small fatty fish, nuts, seeds and olive oil all help. A fish oil or EPA/DHA supplement.  Fish oil, krill oil and particular algae are convenient sources.

1.https://science.sciencemag.org/content/258/5090/1861.long

DRILL DOWN

Pomegranate is an excellent way to increase nitric oxide. It has other beneficial effects on heart health as well. 

Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation https://www.ncbi.nlm.nih.gov/pubmed/15158307

Pomegranate is an excellent way to increase nitric oxide. It has other beneficial effects on heart health as well. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation.

https://www.ncbi.nlm.nih.gov/pubmed/15158307

Extra Virgin Olive Oil

Extra Virgin Olive Oil

2 Tablespoonful’s of Extra Virgin Olive Oil per day can improve our heart health!

It’s simple to keep it handy and use it in or on our food. We have a flavor we like and keep the bottle on the countertop for use on salad, vegetables, and many other foods. It’s amazing how that bottle is gone in a week or two. 

The first pressing of olives (extra virgin olive oil or EVOO) produces a liquid rich in beneficial phenols. Refined olive oils do not have this property. 

We currently use the commonly available and reasonably priced Olive Ranch brand from Southern California. Different flavors are available and begin to rival the nuances of wine tasting. 

Why do we feel this is beneficial to our heart health? Studies have demonstrated that Extra Virgin Olive Oil:

  1. Decreases Inflammation
  2. Increases not only the level of beneficial good cholesterol (HDL) in the blood but quite importantly also increases its functionality.
  3. Lowers blood pressure
  4. Makes us feel full 
  5. Decreases harmful oxidation
  6. Lowers blood sugar 
  7. Increases the body’s sensitivity to insulin

What an easy and tremendous way to improve our HeartHealthToday. 

Further Reading:

Fits M, Cladellas M, de la Torre R, et al. Antioxidant effect of virgin olive oil in patients with stable coronary heart disease: a randomized, crossover, controlled, clinical trial. Atherosclerosis. 2005;181(1):149-158. 

R Madigan C, Ryan M, Owens D, Collins P, Tomkin GH. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care. 2000;23(10):1472-1477 

Bes-Rastrollo M, Sanchez-Villegas A, de la Fuente C, de Irala J, Martinez JA, Martinez-Gonzalez MA. Olive oil consumption and weight change: the SUN prospective cohort study. Lipids. 2006;41(3):249-256

Estruch R, Ros E, Salas-Salvado J, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med. 2013;368(14):1279-1290. 

Babio N, Toledo E, Estruch R, et al. Mediterranean diets and metabolic syndrome status in the PREDIMED randomized trial. CMAJ. 2014;186(17):E649-657. 

Salas-Salvado J, Bullo M, Babio N, et al. Reduction in the incidence of type 2 diabetes with the Mediterranean diet: results of the PREDIMED-Reus nutrition intervention randomized trial. Diabetes Care. 2011;34(1):14-19.

Hearts and Bones

Hearts and Bones

“You take two bodies and you twirl them into one; their hearts and their bones.  And they won’t come undone Hearts and bones”  Paul Simon, 1983

Following the direction of Paul Simon’s 1983 album title song, the latest biological science has uncovered still another strong connection between our hearts and our bones. 

Mutated stem cells deep in our bone marrow can produce a variety of white blood cells which have a particularly inflammatory effect. As they enter the plaque in our blood vessels in an attempt to do their repair job they may well cause increased plaque growth and rupture. Remember that it is the breaking open of a plaque in our blood vessels that causes the sudden heart attack or stroke. 

The practicality of this is that it reinforces our conviction that we must keep unnecessary inflammation to a minimum. 

We should strongly consider avoiding foods that produce inflammation. These are not the same for everyone. Some have trouble with dairy, others shellfish,and some others gluten.  Excess sugar in its many forms can be inflammatory for most. 

Whole food plant based diets are likely one of the most effective ways, but not the only way, to keep inflammation under control. 

Certain foods that fight inflammation include blueberries, green tea, beets, the broccoli family, and our favorite, extra virgin olive oil.  Ginger and turmeric are well known for their property of decreasing inflammation. The most active ingredient of turmeric in this regard appears to be  curcumin. 

What causes the mutations of these stem cells in the first place? Toxins such as certain chemicals and smoke are among the likely culprits.   

These new discoveries have of course produced yet another acronym (C.H.I.P.) standing for –get ready for this one–Clonal Hematopoiesis of Indeterminate Potential.   New CHIP societies and CHIP clinics are already forming and are not to be confused with the kid’s CHIP– Children’s Health Insurance Program.

The studies to date are impressive and may help explain why some of us with few or none of the traditional “risk factors” of high blood pressure, smoking, diabetes and high cholesterol still have heart attacks and strokes.  

We continue to advocate the I CAN DO acronym. The I is for reducing unnecessaryInflammation to improve our Heart Health Today.     

Further Reading:

  1. Jaiswal, S., Natarajan, P., Silver, A. J., Gibson, C. J., Bick, A. G., Shvartz, E., et al. (2017). Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease. N. Engl. J. Med. 377, 111–121. doi: 10.1056/NEJMoa1701719
  2. Jaiswal S, Fontanillas P, Flannick J, et al. Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med 2014;371:2488-2498

3. Is Coronary Atherosclerosis One Disease or Many? Circulation. 2017;135:1005–1007. DOI: 10.1161/CIRCULATIONAHA.116.02


Plaque

Plaque

What is it? Can we measure it?

CORONARY ARTERY CALCIFICATION SCORE – A VALUABLE GUIDE FOR THOSE OF US AT RISK

A simple X-Ray exam that should cost less than $90 is a very accurate measure of the amount of blockage which has developed in our heart arteries. Knowing that number can be an effective motivator for employing an even more effective prevention and reversal program in our lives.

As plaque forms in our arteries, it also becomes calcified, providing a marker that is easily measured by X-Ray. The more calcification, the more plaque, and generally the more serious we must become about managing this health hazard which can result in serious disability or death. 

A score of zero is is normal

1 to 99 indicates mild disease

100 to 399 indicates moderate disease

Over 400 indicates severe disease

Extensive guidelines on the use of this test are available from several sources. 

The score is not perfect. Plaque can occur without calcification, especially in younger individuals.

The test takes about 15 minutes and no dye is used. The radiation exposure is generally minimal, about equivalent to what we get from our surroundings in one year.  The scanners vary widely in the radiation dose, so we pick a good one. Pregnant women or those who may become pregnant should avoid the test. Under age 40, it may not be worth having.

An amazingly comprehensive review of this is contained in the Jan 2018 issue of JACC.

1.Coronary Artery Calcification and its Progression   What Does it Really Mean? Hiroyoshi Mori, Sho Torii, Matthew Kutyna, Atsushi Sakamoto, Aloke V. Finn, Renu Virmani

Journal of the American College of Cardiology: Cardiovascular Imaging Jan 2018, 11 (1) 127-142; DOI:10.1016/j.jcmg.2017.10.012

  1. Coronary Calcium Score and the New Guidelines Javier Sanz

Journal of the American College of Cardiology Oct 2015, 66 (15) 1669-1671; DOI: 10.1016/j.jacc.2015.08.041

Pomegranate

Pomegranate

Can pomegranate improve heart health?

Pomegranate is an excellent way to increase nitric oxide. It has other beneficial effects on heart health as well. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intimamedia thickness, blood pressure and LDL oxidation.

https://lnkd.in/e2AazQ3

Very High Cholesterol

Very High Cholesterol

VERY HIGH CHOLESTEROL

FAMILIAL HYPERLIPIDEMIA – A JOKER IN THE DECK

We are not all biologically alike. The majority of what we hear today unfortunately assumes that we are.

One in very roughly 300 of us in the states have a gene that results in heart disease at a rapid rate. Early disability and death are common if this is the case. The good news is recently there is a valid treatment for this otherwise devastating disorder.

Really, there is nothing fair about it. But then, those with this disorder almost certainly have other genes and characteristics that are entirely fortunate.  

We enjoy a card game and don’t intend to be flippant about this problem, but clearly if one is dealt this card, action is needed. It would be a great card to pass to the player on our left, but then again that is not an option here.

Familial hyperlipidemia (FH), a problem with chromosome 19, results in persistent major increase in bad cholesterol (LDL.) Like many biological situations, it gets very complex and wide ranges of values are confusing. However, if cholesterol is over 280 or LDL over 190, FH may be present. Checking this out is a great choice.   

Presently, 90% of individuals with FH have not been diagnosed.  

We truly enjoy the humor and c’est la vie attitudes we have noted in some with this disorder. Our other thought, however, is that avoiding that Egyptian river known as denial and taking a few serious moments in pursuing this are more than worth it.

Many treatments can help. A new class of medications, PCSK9 inhibitors, are an option and should be carefully considered.

Contact the FH website to get informed. Start to fight this killer with the counsel of your health care professional.

Thefhfoundation.org

Wald, David S.; Bestwick, Jonathan P.; Morris, Joan K.; Whyte, Ken; Jenkins, Lucy; Wald, Nicholas J. (2016). “Child–Parent Familial Hypercholesterolemia Screening in Primary Care”. New England Journal of Medicine375 (17): 1628–1637. doi:10.1056/NEJMoa160277